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Ameliorative Effects of Monascus pilosus-Fermented Black Soybean ( Glycine max L. Merrill) on High-Fat Diet-Induced Obesity.
- Source :
-
Journal of Medicinal Food . Sep2014, Vol. 17 Issue 9, p972-978. 7p. - Publication Year :
- 2014
-
Abstract
- The purpose of this study was to examine the antiobesity effects of Monascus pilosus-fermented black soybean (F-BS) in C57BL/6 mice with high-fat diet (HFD)-induced obesity. F-BS (oral, 0.5 and 1.0 g/kg per body weight, twice per day) ameliorated obesity by reducing body and liver weight increases, and regulating blood glucose and cholesterol levels in C57BL/6 mice fed a control or HFD with oral administration of F-BS for 12 weeks. F-BS suppressed the growth of epididymal, retroperitoneal, and perirenal fat pads by preventing increases in the adipocyte size. Moreover, the levels of blood glucose, total cholesterol, and leptin were significantly lowered by F-BS administration in a dose-dependent manner. These results indicated that F-BS is a beneficial food supplement for preventing obesity, controlling blood glucose, and lowering cholesterol. Future research strategies should address the mechanisms that selectively regulate obesity, including hyperglycemia and hypercholesterolemia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD sugar analysis
*LIVER analysis
*ALTERNATIVE medicine
*ANIMAL experimentation
*ANTHROPOMETRY
*BIOPHYSICS
*CHOLESTEROL
*DIETARY supplements
*DOSE-response relationship in biochemistry
*FAT cells
*FERMENTATION
*FUNGI
*LONGITUDINAL method
*RESEARCH methodology
*MICE
*ORAL drug administration
*SOYBEAN
*ANTIOBESITY agents
*LEPTIN
*STATISTICAL significance
*DESCRIPTIVE statistics
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 17
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 97902823
- Full Text :
- https://doi.org/10.1089/jmf.2012.2740