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pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease.
- Source :
-
International Journal of Pharmaceutics . Oct2014, Vol. 473 Issue 1/2, p203-212. 10p. - Publication Year :
- 2014
-
Abstract
- Nano-scaled particles have been found to preferentially accumulate in inflamed regions. Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment. Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties. Hence, we evaluated, both in vitro and in vivo , the local delivery of CC using pH-sensitive polymeric nanoparticles (NPs) combining both poly(lactide- c o-glycolide) acid (PLGA) and a polymethacrylate polymer (Eudragit ® S100). CC-NPs significantly enhanced CC permeation across Caco-2 cell monolayers when compared to CC in suspension. CC-NPs significantly reduced TNF-α secretion by LPS-activated macrophages (J774 cells). In vivo , CC-NPs significantly decreased neutrophil infiltration and TNF-α secretion while maintaining the colonic structure similar to the control group in a murine DSS-induced colitis model. Our results support the use of nanoparticles made of PLGA and Eudragit ® S100 combination for CC delivery in IBD treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 473
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 97842387
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2014.07.009