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Synthesis and Biological Activity of Triazole-Appended N,O-Nucleosides.
- Source :
-
European Journal of Organic Chemistry . Sep2014, Vol. 2014 Issue 25, p5442-5447. 6p. - Publication Year :
- 2014
-
Abstract
- 1,2,3-Triazole-appended N,O-nucleosides have been synthesized by an approach combining a 1,3-dipolar cycloaddition process and an alkyne-azide click chemistry reaction. Biological assays, performed on six tumor cell lines, revealed the antiproliferative activity of the synthesized compounds. The effect was more evident in the U87MG human glioblastoma cell line. Thus, these nucleoside analogues could be promising scaffolds for the construction of new anticancer agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2014
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 97637321
- Full Text :
- https://doi.org/10.1002/ejoc.201402106