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Retention of a 24-hour time memory in Syrian hamsters carrying the 20-hour short circadian period mutation in casein kinase-1ε (ck1εtau/tau).
- Source :
-
Neurobiology of Learning & Memory . Oct2014, Vol. 114, p171-177. 1p. - Publication Year :
- 2014
-
Abstract
- Circadian rhythmic expression of conditioned place avoidance (CPA) was produced in Syrian hamsters homozygous for the circadian short period mutation, tau. In constant dim red light neither the 20 h endogenous period, nor a 20 h place conditioning schedule eliminated the 24 h modulation of CPA behavior described previously for wild type (wt) hamsters and other species. Tau mutants exhibited a 20 h rhythm superimposed on the 24 h modulation. The 20 h component was removed selectively with lesions of the suprachiasmatic nucleus. Wt animals conditioned on a 20 h schedule did not produce a 20 h rhythm, but still expressed the 24 h modulation. The results show that the context entrainable oscillator (CEO) underlying memory for the timing of an unconditioned stimulus, retains a period of about 24 h regardless of clock gene background (tau mutation) and/or the conditioning schedule (24 vs 20 h). Therefore the CEO responsible for time memory is distinct from the biological clock controlling activity; the underlying circadian molecular mechanisms may differ from the ubiquitous transcription-translation feedback oscillator; and time memory itself is not classically conditioned. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10747427
- Volume :
- 114
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Learning & Memory
- Publication Type :
- Academic Journal
- Accession number :
- 97604939
- Full Text :
- https://doi.org/10.1016/j.nlm.2014.06.004