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Spontaneous Extraskeletal Osteosarcoma in a Rabbit (Oryctolagus cuniculus): Histopathological and Immunohistochemical Findings.

Authors :
Wijesundera, Kavindra Kumara
Takeshi Izawa
Daisuke Fujita
Yuki Denda
Eiko Seto
Hiroshi Sasai
Mitsuru Kuwamura
Jyoji Yamate
Source :
Journal of Toxicologic Pathology. 2013, Vol. 26 Issue 3, p309-312. 4p.
Publication Year :
2013

Abstract

A spontaneously occurring subcutaneous mass in the left forelimb of a nine-year-old rabbit (Oryctolagus cuniculus) was examined histopathologically and immunohistochemically. Clinically, edema and hemorrhage were seen around the mass. No connection of the tumor mass to the appendicular skeleton was found. The tumor was arranged in a solid growth pattern and irregular bundles, and neoplastic cells were polygonal to spindle-shape. Osteoid (positive for osteocalcin) and multinucleated giant cells were diffusely or focally seen. Neoplastic cells were positive for vimentin, osterix and Ki-67, indicating the nature of osteoblasts with proliferating activity, but negative for a-smooth muscle actin, desmin or CD204. Based on these findings, a diagnosis of extraskeletal osteosarcoma was made, a very rare tumor both in laboratory and pet rabbits. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09149198
Volume :
26
Issue :
3
Database :
Academic Search Index
Journal :
Journal of Toxicologic Pathology
Publication Type :
Academic Journal
Accession number :
97505498
Full Text :
https://doi.org/10.1293/tox.26.309