Maligní nádory vzniklé po úspěšné léčbě akutní myeloidní leukemie u dospělých nemocných: dlouhodobé zkušenosti jednoho pracoviště.

Introduction. Current curative treatment of acute myeloid leukemia is based on intensive chemotherapy and hematopoietic stem cell transplantation with a significant risk of severe adverse effects, including leukemogenic and cancerogenic ones. Objectives. The study is aimed at assessing of incidence and types of malignant tumours in successfully treated acute myeloid leukemia patients. Methods. A retrospective analysis consists of 256 patients diagnosed with acute myeloid leukemia at the Department of Hemato-Oncology in Olomouc in 1996-2008 who were treated with intensive chemotherapy and achieved complete remission of the disease. Results. Second malignancy occurred in 11 individuals (4.3%) after successful treatment of acute myeloid leukemia. Observed age-standardized incidence of these tumours, 8.29/1,000 person-years, 95% Cl = (2.99; 13.58), was not significantly different from the incidence in population. Five patients died of the second malignancy. [ABSTRACT FROM AUTHOR]