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Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in Illicit Drug Use and Drug-Related Psychiatric Disorders.
- Source :
-
Substance Use & Misuse . Sep2014, Vol. 49 Issue 11, p1385-1391. 7p. 4 Charts. - Publication Year :
- 2014
-
Abstract
- To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met ( p = 0.039) but not in allele frequencies of DAT1 3′-UTR VNTR ( p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3′-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SUICIDE risk factors
*AFFECTIVE disorders
*SUBSTANCE abuse
*SUBSTANCE abuse risk factors
*CHI-squared test
*CONFIDENCE intervals
*DOPAMINE
*FISHER exact test
*GENES
*GENETIC polymorphisms
*GENETICS
*DATA analysis software
*DESCRIPTIVE statistics
*ODDS ratio
*MENTAL illness risk factors
PSYCHOSES risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 10826084
- Volume :
- 49
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Substance Use & Misuse
- Publication Type :
- Academic Journal
- Accession number :
- 97252108
- Full Text :
- https://doi.org/10.3109/10826084.2014.901391