The relationship between neutrophil to lymphocyte ratio and SYNTAX score in patients with ST-segment elevation myocardial infarction.

Objective: We aimed to assess relationship between the severity of coronary atherosclerosis assessed by SYN­TAX score (SS) and neutrophil to lymphocyte ratio (NLR) in patients with ST elevation myocardial infarction (STE­MI. Methods: After accounting for exclusion criteria, a total of 291 patient with STEMI in whom primary percutaneous coronary intervention was performed were retrospective­ly included (216 male, 75 female; mean age 61.6+14.0 years). Total and differential leukocyte counts and other biochemical markers were measured at admission. Pa­tients were categorized into tertiles on the basis of SS. Monitoring for major adverse cardiac events (MACEs) was performed during the in hospital follow-up period. Results: The SS high group leukocyte (p=0.009), neutro­phil (p=0.008), NLR (p=0.048), peak troponin (p<0.001), peak CK-MB (p=0.001) lactate dehydrogenase (p=0.005), aspartate aminotransferase (p=0.004) values were signif­icantly higher compared with SSlow and SSmid groups. SS was increased, left ventricular ejection fraction was decrease (p<0.001) and left ventricular systolic diameter was increased (p=0.007). The in-hospital death rate and MACEs were greater in the high SS group than in the other groups (p<0.001 both of). Conclusion: We found that high NLR was significantly and correlated increased with SS. In addition, high SS were significantly associated with increased in-hospital MACE and in-hospital death. Further prospective studies assessing the predictive role of both SS and NLR in con­junction for risk stratification might improve risk predic­tion in patients with STEMI. [ABSTRACT FROM AUTHOR]