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The future of whole-cell modeling.
- Source :
-
Current Opinion in Biotechnology . Aug2014, Vol. 28, p111-115. 5p. - Publication Year :
- 2014
-
Abstract
- Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine--once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09581669
- Volume :
- 28
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 97199263
- Full Text :
- https://doi.org/10.1016/j.copbio.2014.01.012