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Wet-spun poly(ε-caprolactone) microfiber scaffolds for oriented growth and infiltration of smooth muscle cells.
- Source :
-
Materials Letters . Oct2014, Vol. 132, p59-62. 4p. - Publication Year :
- 2014
-
Abstract
- The tissue engineered blood vessel requires oriented fibrous scaffold as template to guide smooth muscle cells (SMCs) oriented growth and infiltration. It is a considerable challenge to fabricate this kind of fibrous scaffold. In this letter, we developed a new wet-spinning system that involves a blended solution of edible oil and hexane as a non-solvent coagulation bath to fabricate oriented poly(ε-caprolactone) (PCL) microfiber scaffold. The fiber diameter and porosity could be controlled in the range of 7 to 27 μm and 68 to 82%, respectively. SMCs could grow in an oriented fashion along the fibers and infiltrate inside the scaffold as well as maintain SMCs phenotype. This oriented microfiber scaffold has a promising potential for regenerating blood vessels and other fibrous tissues such as tendon, ligament and intervertebral discs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0167577X
- Volume :
- 132
- Database :
- Academic Search Index
- Journal :
- Materials Letters
- Publication Type :
- Academic Journal
- Accession number :
- 97187382
- Full Text :
- https://doi.org/10.1016/j.matlet.2014.06.038