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Etifoxine provides benefits in nerve repair with acellular nerve grafts.
- Source :
-
Muscle & Nerve . Aug2014, Vol. 50 Issue 2, p235-243. 9p. - Publication Year :
- 2014
-
Abstract
- ABSTRACT Introduction: Acellular nerve grafts are good candidates for nerve repair, but the clinical outcome of grafting is not always satisfactory. We investigated whether etifoxine could enhance nerve regeneration. Methods: Seventy-two Sprague-Dawley rats were divided into 3 groups: (1) autograft; (2) acellular nerve graft; and (3) acellular nerve graft plus etifoxine. Histological and electrophysiological examinations were performed to evaluate the efficacy of nerve regeneration. Walking-track analysis was used to examine functional recovery. Quantitative polymerase chain reaction was used to evaluate changes in mRNA level. Results: Etifoxine: (i) increased expression of neurofilaments in regenerated axons; (ii) improved sciatic nerve regeneration measured by histological examination; (iii) increased nerve conduction velocity; (iv) improved walking behavior as measured by footprint analysis; and (v) boosted expression of neurotrophins. Conclusions: These results show that etifoxine can enhance peripheral nerve regeneration across large nerve gaps repaired by acellular nerve grafts by increasing expression of neurotrophins. Muscle Nerve 50:235-243, 2014 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0148639X
- Volume :
- 50
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Muscle & Nerve
- Publication Type :
- Academic Journal
- Accession number :
- 97130937
- Full Text :
- https://doi.org/10.1002/mus.24131