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Pathologic prognostic factors in stage I-III uterine carcinosarcoma treated with postoperative radiotherapy.
- Source :
-
Archives of Gynecology & Obstetrics . Aug2014, Vol. 290 Issue 2, p329-334. 6p. 3 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Purpose: To analyse the impact of prognostic factors on specific overall survival (SOS) after postoperative radiotherapy (P-RT) in carcinosarcomas. Methods: We retrospectively analysed 81 patients who received P-RT from 1977 to 2010 after the diagnosis of carcinosarcomas. 2009 FIGO stage: 25-IA, 20-IB, 6-II, 9-IIIA, 11-IIIC. Age, stage, vascular and lymphatic space invasion (VLSI), myometrial invasion, grade, mitotic index, sarcomatous/epithelial components, tumour size and necrosis were considered for the analysis. Statistics: we used the Kaplan-Meier method for survival analysis and the Cox model for risk factor evaluation. Results: The mean follow-up of the series was 78.86 months (range 7-381). The median age was 72 years (range 51-89). 30 out 81 (37 %) patients relapsed and died (22.2 % pelvic and abdominal, 13.5 % exclusive distant metastasis). On univariate and multivariate analysis only stage had a significant impact on SOS. At 5 years, stage I-II had a SOS of 66 % in comparison with stage III with 30 %. Conclusions: Two groups of patients showing different outcome were found after P-RT in uterine carcinosarcomas: stage I-II patients had a life expectancy 2.5-fold longer compared to stage III patients. New therapeutic strategies are warranted in carcinosarcomas considering the high incidence of distant metastasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09320067
- Volume :
- 290
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Archives of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 97072352
- Full Text :
- https://doi.org/10.1007/s00404-014-3202-z