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Urinary Podocyte Excretion and Proteinuria in Patients Treated with Antivascular Endothelial Growth Factor Therapy for Solid Tumor Malignancies.
- Source :
-
Oncology . Jul2014, Vol. 86 Issue 5/6, p271-278. 8p. 1 Black and White Photograph, 2 Charts, 2 Graphs. - Publication Year :
- 2014
-
Abstract
- Background: Urinary podocyte excretion (podocyturia) may function as a more specific marker of ongoing glomerular damage. This study sought to analyze the relationship between proteinuria and podocyturia in cancer patients treated with antivascular endothelial growth factor (anti-VEGF) agents. Methods: Thirty-seven patients treated with anti-VEGF medications were analyzed in a single-institution, cross-sectional study. Podocyte cultures were performed on random urine collections (50-100 ml), and podocytes were identified by positive podocin staining. The corresponding urine samples were analyzed for protein and creatinine (Cr) measurements. Results: Proteinuria ≥0.5 g/g Cr was found in 30% of the patients (median, 0.12; interquartile range, 0.04-0.86), and 62% had podocyturia. There was a significant difference in the amount of podocyturia between patients with proteinuria ≥0.5 g/g Cr and those with a value <0.5 g/g Cr (median podocyturia, 1.08 cells/mg Cr, range, 0-14.55 vs. 0.03 cells/mg Cr, range, 0-1.64, respectively; p < 0.001). A statistically significant correlation was observed between the cumulative dose of bevacizumab and both proteinuria (r = 0.48, p = 0.004) and podocyturia (r = 0.34, p = 0.045) as well as between proteinuria and podocyturia (r = 0.63, p < 0.001), suggesting that these are mechanistically related. Discussion: Ongoing podocyte loss may be mechanistically related to the onset and severity of proteinuria in patients treated with anti-VEGF agents. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENDOTHELIAL growth factors
*ACADEMIC medical centers
*CHI-squared test
*CREATININE
*HYPERTENSION
*MEDICAL records
*PROTEINURIA
*STATISTICS
*TUMORS
*URINALYSIS
*DATA analysis
*VASCULAR endothelial growth factors
*PROPORTIONAL hazards models
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*PATHOLOGIC neovascularization
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00302414
- Volume :
- 86
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 96983945
- Full Text :
- https://doi.org/10.1159/000360180