Days of the Elevated Level of Serum Progesterone before Follicular Maturation are Related with Outcomes of IVF/ICSI-ET Treatment.

Objective: To explore the effect of days of the elevated serum progesterone before hCG administration on the outcomes of IVF/ICSI-ET treatment. Methods: 2 905 cases of IVF/ICSI -ET treatment, from June 2012 to June 2013, were divided into two groups according to whether finding the follicle (s) of diameter ≥ 20 mm (Group A 2 725 cases, and Group B 180 cases) on the hCG day. Two groups were respectively divided into 3 subgroups according to days of the elevated level of progesterone (>1 ng/mL). Group A1 (1 788 cases) and B1 (83 cases) had 0 day of the elevated level of progesterone. Group A2 (717 cases) and B2 (67 cases) had 1-2 days of the elevated level of progesterone. Groups A3 (220 cases) and B3 (30 cases) had ≥3 days of the elevated level of progesterone. The clinical pregnancy rates of groups were meticulously compared. Results: There was significant difference in the clinical pregnancy rates among the Group A1 (55.42%), A2 (44.21%) and A3 (41.81%, P<0.01). Interestingly, there was no significant difference in those rates among the Group B1 (48.19%), B2 (47.76%) and B3 (46.66%, P>0.05). Conclusions: The clinical pregnancy rate could decrease following days of the elevated level of serum progesterone (>1 ng/mL) in those IVF/ICSI-ET patients with the follicle(s) of diameter ≥20 mm on the hCG day. [ABSTRACT FROM AUTHOR]