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Quantitative liquid chromatography–tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile.
- Source :
-
Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences . Jul2014, Vol. 963, p113-118. 6p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] A LC–MS/MS method for MC-RR and metabolites in plasma and bile was developed and validated. [•] Liquid–liquid and solid-phase extraction maximally enhance responses of analytes. [•] Limited biological liquid samples are important in the detoxification of MC-RR. [•] The developed assay was successfully utilized to examine toxicokinetics of MCs in plasma and bile. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15700232
- Volume :
- 963
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 96787356
- Full Text :
- https://doi.org/10.1016/j.jchromb.2014.05.057