Quantitative liquid chromatography–tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile.

Authors :: Li, Wei
Xie, Ping
Chen, Jun
He, Jun
Guo, Xiaochun
Yu, Dezhao
Chen, Liang
Source :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Jul2014, Vol. 963, p113-118. 6p.
Publication Year :: 2014
Abstract: Highlights: [•] A LC–MS/MS method for MC-RR and metabolites in plasma and bile was developed and validated. [•] Liquid–liquid and solid-phase extraction maximally enhance responses of analytes. [•] Limited biological liquid samples are important in the detoxification of MC-RR. [•] The developed assay was successfully utilized to examine toxicokinetics of MCs in plasma and bile. [ABSTRACT FROM AUTHOR]

Subjects :: *LIQUID chromatography-mass spectrometry
*MICROCYSTINS
*QUANTITATIVE research
*GLUTATHIONE
*CYSTEINE
*FISH metabolism
*BILE
*LIQUID-liquid extraction

Language :: English
ISSN :: 15700232
Volume :: 963
Database :: Academic Search Index
Journal :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :: Academic Journal
Accession number :: 96787356
Full Text :: https://doi.org/10.1016/j.jchromb.2014.05.057

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