Back to Search
Start Over
Dopamine Transporter Genotype and Stimulant Dose-Response in Youth with Attention-Deficit/Hyperactivity Disorder.
- Source :
-
Journal of Child & Adolescent Psychopharmacology . Jun2014, Vol. 24 Issue 5, p238-244. 7p. - Publication Year :
- 2014
-
Abstract
- Objectives: This study seeks to determine if variation in the dopamine transporter gene (SLC6A3/DAT1) moderates the dose-response effects of long-acting dexmethylphenidate (D-MPH) and mixed amphetamine salts (MAS) in children with attention-deficit/hyperactivity disorder (ADHD). Methods: Fifty-six children and adolescents (mean age=11.7±2.2) participated in a double-blind, two period crossover, dose-response study with a randomized placebo week in each 4 week drug period. Each period consisted of sequential week-long exposures to three dose levels (10, 20, 25-30 mg, depending upon weight) of D-MPH or MAS. Results: Doses of 10-20 mg of either D-MPH or MAS had little to no effect on hyperactivity-impulsivity and total ADHD symptom scores in subjects with the 9/9 genotype; this was in contrast to the dose-response curves of subjects with either the 10/10 or 10/9 genotype. Conclusions: ADHD youth with the 9/9 genotype may require higher stimulant doses to achieve adequate symptom control. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10445463
- Volume :
- 24
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Child & Adolescent Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 96665838
- Full Text :
- https://doi.org/10.1089/cap.2013.0102