Arsonists and Firefighters.

The author comments on the paper "Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in Apolipoprotein E-/- mice and rabbits fed a high fat and -cholesterol diet" by S. Chaterjee and colleagues. Topics discussed include the effects of the glycosphingolipids (GSL) synthesis inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and the influence of GSL synthesis inhibition on atherosclerosis and cholesterol metabolism.