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The impairment in spatial learning and hippocampal LTD induced through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function.
- Source :
-
Neuroscience Research . Apr2014, Vol. 81-82, p55-63. 9p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Memantine rescued hippocampal-dependent memory and hippocampal LTD in JDM rats. [•] LTD was impaired by a malfunction in NR2B-containing NMDA receptors in JDM rats. [•] Abnormal NMDA receptor function was caused by excessive PKA activity in JDM rats. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01680102
- Volume :
- 81-82
- Database :
- Academic Search Index
- Journal :
- Neuroscience Research
- Publication Type :
- Academic Journal
- Accession number :
- 96445729
- Full Text :
- https://doi.org/10.1016/j.neures.2014.02.002