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Label-Free Sensing of Biomolecules with Field-Effect Devices for Clinical Applications.
- Source :
-
Electroanalysis . Jun2014, Vol. 26 Issue 6, p1197-1213. 17p. - Publication Year :
- 2014
-
Abstract
- Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10400397
- Volume :
- 26
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Electroanalysis
- Publication Type :
- Academic Journal
- Accession number :
- 96364146
- Full Text :
- https://doi.org/10.1002/elan.201400073