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Applications of low-intensity pulsed ultrasound to increase monoclonal antibody production in CHO cells using shake flasks or wavebags.
- Source :
-
Ultrasonics . Aug2014, Vol. 54 Issue 6, p1439-1447. 9p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] The use of low intensity pulsed ultrasound (LIPUS) to increase antibody production. [•] Daily ultrasound increase up to 35% in antibody production in shake flask. [•] A scaled-up wave-bag configuration increased antibody production by 25% with sonication. [•] Physical effects of LIPUS increase cell permeability and thus enhance cell metabolism. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0041624X
- Volume :
- 54
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Ultrasonics
- Publication Type :
- Academic Journal
- Accession number :
- 96342197
- Full Text :
- https://doi.org/10.1016/j.ultras.2014.04.025