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Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen.

Authors :
Jiang, Yi-Zhou
Li, Yan
Wang, Kai
Dai, Cai-Feng
Huang, Shi-An
Chen, Dong-Bao
Zheng, Jing
Source :
Molecular & Cellular Endocrinology. Jun2014, Vol. 391 Issue 1/2, p60-67. 8p.
Publication Year :
2014

Abstract

Highlights: [•] HIF1A overexpression enhanced endothelial proliferation and/or migration in 21% O2. [•] HIF1A knockdown failed to affect endothelial proliferation and migration in 3% O2. [•] HIF1A critically regulates human endothelial function in 21% O2, but not in 3% O2. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03037207
Volume :
391
Issue :
1/2
Database :
Academic Search Index
Journal :
Molecular & Cellular Endocrinology
Publication Type :
Academic Journal
Accession number :
96233313
Full Text :
https://doi.org/10.1016/j.mce.2014.04.008