Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress.

Highlights: [•] Nrf2 is upregulated in islets at early stage of diabetes in human. [•] Activation of Nrf2 by dh404 suppresses oxidative stress and prevents oxidative stress-induced β-cell apoptosis. [•] Activation of Nrf2 by dh404 enhances oxidative stress-induced autophagic clearance of ubiquitinated proteins in islets. [Copyright &y& Elsevier]