JAK/STAT pathway dysregulation in tumors: A Drosophila perspective.

Highlights: [•] JAK/STAT signaling is central to epithelial and hematopoietic tumors in Drosophila. [•] Unpaired is ectopically induced by loss of distinct tumor suppressors. [•] Ras and JAK/STAT pathways cooperate to induce metastatic tumors. [•] Dominant-active JAK mutations cause melanotic tumors, a fly leukemia. [•] Genetic screens have identified new pathway effectors in blood cell tumors. [Copyright &y& Elsevier]