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Pharmacokinetics and safety of cetuximab in a patient with renal dysfunction.
- Source :
-
Cancer Chemotherapy & Pharmacology . Jun2014, Vol. 73 Issue 6, p1303-1306. 4p. - Publication Year :
- 2014
-
Abstract
- Introduction: In the literature, data on the effect of renal impairment on the pharmacokinetics of anticancer drugs are scarce. Here, we report a 68-year-old metastatic osteosarcoma patient with impaired renal function due to prior chemotherapy, who was treated on compassionate use basis with 400 mg/m cetuximab. Material and methods: Pharmacokinetic parameters after the first dose, including dose-normalised AUC from time zero to day 7, clearance, elimination half-life ( t), were estimated using trapezoidal non-compartmental methods and compared to pharmacokinetic data from a study population with normal kidney function. Results: The results showed that the pharmacokinetics of cetuximab in this patient with renal failure was similar to that with adequate renal function. Conclusion: This study suggests that cetuximab can be safely used in cancer patients with renal impairment without dose adjustment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03445704
- Volume :
- 73
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Cancer Chemotherapy & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 96202695
- Full Text :
- https://doi.org/10.1007/s00280-014-2462-4