Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids.

Describes the solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Preparation of two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, on a 50 gram scale without column chromatography; Optimization of cycling protocols to afford high stepwise coupling yields; Deprotection by aminolysis.