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A ΔdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation.
- Source :
-
Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis . May2014, Vol. 763-764, p19-27. 9p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] We describe Δ(dinB-yafN)883(::kan), a novel dinB allele, referred to as ΔdinB883, a deletion that sensitizes E. coli cells to UV irradiation. [•] This UV radiation sensitivity is most acute in the early logarithmic phase of culture growth. [•] This UV radiation sensitivity is completely dependent upon a functional umuDC operon. [•] Sequencing reveals ΔdinB883 retains the proximal 161 nucleotides, i.e., 54 amino acids, of the wild-type sequence. [•] The ΔdinB883 mutant is hypothesized to produce a peptide of 83 amino acids, DinB883, that compromises UmuDC function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00275107
- Volume :
- 763-764
- Database :
- Academic Search Index
- Journal :
- Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 96028885
- Full Text :
- https://doi.org/10.1016/j.mrfmmm.2014.03.003