Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin.

Highlights: [•] DINP-exposed toxicity is associated with the overproduction of ROS. [•] Oral exposure to DINP is likely to present hepatic and renal tissue injury. [•] ROS accumulation maybe further causes IL-1 and TNF-α production at increased levels. [ABSTRACT FROM AUTHOR]