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Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells.
- Source :
-
Reproductive Toxicology . Jun2014, Vol. 45, p87-93. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] LPS reduces the expression of GDNF in Sertoli cells and its conditioned media but not BMP4 or SCF. [•] LPS can decrease the expression of SSC self-renewal genes and increase the expression of SSC differentiation genes. [•] LPS can also depress the expression of GDNF downstream genes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08906238
- Volume :
- 45
- Database :
- Academic Search Index
- Journal :
- Reproductive Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 96026356
- Full Text :
- https://doi.org/10.1016/j.reprotox.2014.01.009