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Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability.

Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability.

Authors :
Piccart, Elisabeth
De Backer, Jean-François
Gall, David
Lambot, Laurie
Raes, Adam
Vanhoof, Greet
Schiffmann, Serge
D’Hooge, Rudi
Source :
Behavioural Brain Research. Jul2014, Vol. 268, p48-54. 7p.
Publication Year :
2014

Abstract

Highlights: [•] PDE10A knockout mice show impaired attribution of incentive salience, evident in an instrumentally conditioned reinforcement task. [•] Latent inhibition and prepulse inhibition remain largely intact in PDE10A-deficient animals. [•] Striatal medium spiny neuron excitability is decreased in PDE10A knockout animals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01664328
Volume :
268
Database :
Academic Search Index
Journal :
Behavioural Brain Research
Publication Type :
Academic Journal
Accession number :
96024700
Full Text :
https://doi.org/10.1016/j.bbr.2014.03.016