Lysosomal degradation of ubiquitin-tagged receptors.

Discusses a paper by L. Hicke and H. Riezman which indicates that ubiquitinated membrane proteins are marked for proteolysis in vacuoles, not by the proteasome. The membrane protein, cystic fibrosis transmembrane conductance regulator; How a protein can be degraded as a result of its ubiquitination even when it cannot be accessed by the proteasome.