P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones.

Highlights: [•] P-glycoprotein mediates the collateral sensitivity of MDR cells to steroid hormones. [•] Stimulation of P-glycoprotein ATPase by steroid hormones is likely causative of collateral sensitivity in MDR cells. [•] Steroid hormones synergize with mETC decoupling drugs to induce collateral sensitivity. [•] Verapamil negatively modulates steroid hormones-induced collateral sensitivity. [ABSTRACT FROM AUTHOR]