Back to Search
Start Over
Slight Alteration of the Electroretinogram in Mice Lacking Dystrophin Dp71.
- Source :
-
Ophthalmic Research . May2014, Vol. 51 Issue 4, p196-203. 8p. - Publication Year :
- 2014
-
Abstract
- Aim: Most Duchenne muscular dystrophy patients and the mdxCv3 mouse strain, lacking expression of both dystrophins Dp260 and Dp71, show a high attenuation of the dark-adapted electroretinogram (ERG) b-wave amplitude, whereas mice lacking the expression of Dp260 show normal b-wave amplitude. Here, we completed our assessment of whether the sole absence of Dp71 affects the ERG. Methods: Ganzfeld ERGs were performed on dark-adapted Dp71-null mice and littermates. Scotopic flash ERGs were recorded at light intensities from 3.10−5 to 1 cd.s/m2. Oscillatory potentials (OPs) were extracted at 1 cd.s/m2. Photopic flash ERGs were recorded at 10 cd.s/m2 after light adaptation. Results: Dp71-null mice showed a slight but significant reduction in b-wave amplitudes, normal a-wave amplitudes and nonaffected implicit times of the scotopic ERGs. No changes were observed in the amplitudes and implicit times of the OPs and the photopic ERGs. Conclusions: Our results demonstrate that together both Dp71 and Dp260 are required for the generation of the ERG b-wave in mice. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICE
*MURIDAE
*DYSTROPHIN
*CYTOSKELETAL proteins
*DUCHENNE muscular dystrophy
Subjects
Details
- Language :
- English
- ISSN :
- 00303747
- Volume :
- 51
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Ophthalmic Research
- Publication Type :
- Academic Journal
- Accession number :
- 95976344
- Full Text :
- https://doi.org/10.1159/000357272