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Slight Alteration of the Electroretinogram in Mice Lacking Dystrophin Dp71.

Authors :
Cia, David
Simonutti, Manuel
Fort, Patrice E.
Doly, Michel
Rendon, alvaro
Source :
Ophthalmic Research. May2014, Vol. 51 Issue 4, p196-203. 8p.
Publication Year :
2014

Abstract

Aim: Most Duchenne muscular dystrophy patients and the mdxCv3 mouse strain, lacking expression of both dystrophins Dp260 and Dp71, show a high attenuation of the dark-adapted electroretinogram (ERG) b-wave amplitude, whereas mice lacking the expression of Dp260 show normal b-wave amplitude. Here, we completed our assessment of whether the sole absence of Dp71 affects the ERG. Methods: Ganzfeld ERGs were performed on dark-adapted Dp71-null mice and littermates. Scotopic flash ERGs were recorded at light intensities from 3.10−5 to 1 cd.s/m2. Oscillatory potentials (OPs) were extracted at 1 cd.s/m2. Photopic flash ERGs were recorded at 10 cd.s/m2 after light adaptation. Results: Dp71-null mice showed a slight but significant reduction in b-wave amplitudes, normal a-wave amplitudes and nonaffected implicit times of the scotopic ERGs. No changes were observed in the amplitudes and implicit times of the OPs and the photopic ERGs. Conclusions: Our results demonstrate that together both Dp71 and Dp260 are required for the generation of the ERG b-wave in mice. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00303747
Volume :
51
Issue :
4
Database :
Academic Search Index
Journal :
Ophthalmic Research
Publication Type :
Academic Journal
Accession number :
95976344
Full Text :
https://doi.org/10.1159/000357272