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Hydroxyethyl Starch-induced Pruritus: Clinical Characteristics and Influence of Dose, Molecular Weight and Substitution.
- Source :
-
Acta Dermato-Venereologica . May2014, Vol. 94 Issue 3, p282-287. 6p. - Publication Year :
- 2014
-
Abstract
- Severe persistent pruritus is a common, but incompletely characterized, complication of hydroxyethyl starch (HES) infusion. This retrospective study aimed to assess HES-induced pruritus by electron microscopic findings, pruritus characteristics, and response to stimuli, and to determine the impact of HES dosage, molecular weight and substitution. Seventy patients with electron microscopy-proven HES-induced pruritus were included. HES-laden vacuoles were observed in skin macrophages of all patients. The median latency between HES exposure and pruritus onset was 3 weeks, and the median duration of pruritus was 6 months. Pruritus was severe, or very severe, in 80% of patients. Mechanical stimuli triggered pruritus in 74% of patients. Although the median cumulative dose of HES was 300 g, 15% of patients developed pruritus after only 30 g. There were no significant differences between HES 130/0.4 and HES 200/0.5 in pruritus latency, duration or severity. HES-induced pruritus thus may occur at any dose, molecular weight or substitution. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ITCHING
*HYDROXYETHYL starch
*ELECTRON microscopy
*MACROPHAGES
*MOLECULAR weights
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 94
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 95901651
- Full Text :
- https://doi.org/10.2340/00015555-1639