Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.

Highlights: [•] EV71 and CVA16 display different cytotoxic effects and type I IFN induction patterns in RD cells. [•] EV71 has more resistance to type I IFN inhibitory effect than CVA16. [•] EV71 and CA16 display different regulation patterns on 84 genes related to type I IFN pathway. [•] EV71 infection represses the JAK-STAT pathway and IFN-stimulated genes expression in RD cells. [ABSTRACT FROM AUTHOR]