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A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
- Source :
-
Annals of Neurology . Apr2014, Vol. 75 Issue 4, p602-607. 6p. - Publication Year :
- 2014
-
Abstract
- Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aβ production. Ann Neurol 2014;75:602-607 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03645134
- Volume :
- 75
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Annals of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 95864383
- Full Text :
- https://doi.org/10.1002/ana.24130