Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.

Highlights: [•] A Drosophila sodium channel, DmNav7-1, exhibits a unique persistent current (I NaP). [•] This I NaP activates over a broad voltage range. [•] I260T contributes to I NaP at hyperpolarizing potentials via enhancement of window currents. [•] A1731V contributes to I NaP at depolarizing potentials probably by inhibiting the outward movement of IVS4. [ABSTRACT FROM AUTHOR]