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Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons.
- Source :
-
Neuroscience Letters . May2014, Vol. 569, p142-147. 6p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Exposure of valproic acid to cultured cortical neurons decreased VGAT expression. [•] The reduction of VGAT by valproic acid was through its HDAC inhibition activity. [•] Valproic acid suppressed the formation of inhibitory synapses. [•] Valproic acid may disturb the brain development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 569
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95828015
- Full Text :
- https://doi.org/10.1016/j.neulet.2014.03.066