Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.

Highlights: [•] FMR1 KO Fragile X syndrome model mice show impaired prepulse inhibition (PPI). [•] CGG repeat knockin FXTAS model mice show impaired prepulse inhibition. [•] These prepulse inhibition abnormalities in CGG knockin mice are age-dependent. [•] Fmr1 KO and CGG knockin animals share an impaired PPI phenotype. [ABSTRACT FROM AUTHOR]