A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on Generalized Modules for Membrane Antigens (GMMA).

Highlights: [•] An affordable broadly-protective vaccine against meningococcus is needed for Africa. [•] Generalised modules for membrane antigens (GMMA) are a novel vaccine approach. [•] We engineered a GMMA-based vaccine with over-expressed factor H binding protein. [•] Mutation led to capsule deletion, reduced reactogenicity and increased GMMA release. [•] Vaccination induced bactericidal antibodies against African A, W and X strains. [Copyright &y& Elsevier]