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Getting RIDD of RNA: IRE1 in cell fate regulation.
- Source :
-
Trends in Biochemical Sciences . May2014, Vol. 39 Issue 5, p245-254. 10p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] XBP1 splicing and RIDD activities are differentially regulated functions of the UPR transducer IRE1. [•] RIDD is a conserved ancestral mechanism regulating proteostasis in different eukaryotic phyla. [•] RIDD has a basal activity that is required to maintain ER homeostasis. [•] XBP1 splicing and RIDD produce opposite effects on cell fate in cells subjected to ER stress. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680004
- Volume :
- 39
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Trends in Biochemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 95812931
- Full Text :
- https://doi.org/10.1016/j.tibs.2014.02.008