Back to Search
Start Over
Analysis of Long-Term Depression in the Purkinje Cell Circuit (a Model Study).
- Source :
-
Neurophysiology . Feb2014, Vol. 46 Issue 1, p25-32. 8p. - Publication Year :
- 2014
-
Abstract
- In the cerebellum, long-term depression (LTD) plays a key function in sculpting neuronal circuits to store information, since motor learning and memory are thought to be associated with such long-term changes in synaptic efficacy. To better understand the principles of transmission of information in the cerebellum, we, in our model, distinguished different types of neurons (type 1- and type 2-like) to examine the neuronal excitability and analyze the interspike interval (ISI) bifurcation phenomenon in these units, and then built a Purkinje cell circuit to study the impact of external stimulation on LTD in this circuit. According to the results of computational analysis, both climbing fiber-Purkinje cell and granule cell-Purkinje cell circuits were found to manifest LTD; the external stimuli would influence LTD by changing both depression time and depression intensity. All of the simulated results showed that LTD is a very significant factor in the Purkinje circuit networks. Finally, to deliver the learning regularities, we simulated spike timing-dependent plasticity (STDP) by increasing the CaP conductance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00902977
- Volume :
- 46
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 95799747
- Full Text :
- https://doi.org/10.1007/s11062-014-9402-0