GLMMLasso: An Algorithm for High-Dimensional Generalized Linear Mixed Models Using ℓ 1 -Penalization.

We propose an ℓ1-penalized algorithm for fitting high-dimensional generalized linear mixed models (GLMMs). GLMMs can be viewed as an extension of generalized linear models for clustered observations. Our Lasso-type approach for GLMMs should be mainly used as variable screening method to reduce the number of variables below the sample size. We then suggest a refitting by maximum likelihood based on the selected variables only. This is an effective correction to overcome problems stemming from the variable screening procedure that are more severe with GLMMs than for generalized linear models. We illustrate the performance of our algorithm on simulated as well as on real data examples. Supplementary materials are available online and the algorithm is implemented in the R packageglmmixedlasso. [ABSTRACT FROM PUBLISHER]