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Umbrella sampling of proton transfer in a creatine–water system.

Authors :
Ivchenko, Olga
Bachert, Peter
Imhof, Petra
Source :
Chemical Physics Letters. Apr2014, Vol. 600, p51-55. 5p.
Publication Year :
2014

Abstract

Highlights: [•] First principles simulation of prototypical metabolite molecule. [•] Free energy barrier of proton transfer reaction underlying chemical exchange saturation transfer experiments. [•] Spontaneous proton back transfer. [•] Proton readily releases on biological time scales. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00092614
Volume :
600
Database :
Academic Search Index
Journal :
Chemical Physics Letters
Publication Type :
Academic Journal
Accession number :
95723146
Full Text :
https://doi.org/10.1016/j.cplett.2014.03.045