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The association between neutropenia and prognosis in stage III colorectal cancer patients receiving adjuvant chemotherapy.
- Source :
-
European Journal of Cancer Care . May2014, Vol. 23 Issue 3, p394-400. 7p. 3 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Neutropenia during chemotherapy has been reported to be a predictor of better survival in patients with several types of cancer, although there are no reports on stage III colorectal cancer ( CRC). The purpose of this study was to examine the association between neutropenia and prognosis in stage III CRC patients receiving adjuvant chemotherapy consisting of oral uracil and tegafur ( UFT) plus leucovorin ( LV). We retrospectively analysed 123 patients with stage III CRC who received UFT/ LV as adjuvant chemotherapy. The end-point was disease-free survival ( DFS). Survival curves of the two categories (neutropenia absent vs. present) were estimated using the Kaplan- Meier method and compared by the log-rank test. We estimated the hazard ratio ( HR) for DFS according to neutropenia after adjustment for covariates by multivariate analyses using Cox's regression analysis. A total of 33 (26.8%) patients experienced neutropenia. Patients without neutropenia showed a significantly lower DFS than those with neutropenia (3-year DFS 57.3% vs. 81.2%, P = 0.0213). By multivariate analysis, neutropenia and histological type were independent prognostic factors, with HR of 0.410 (neutropenia absent vs. present, P = 0.045) and 4.793 (well to moderately differentiated vs. poorly differentiated, P = 0.004) respectively. We demonstrated that neutropenia occurring during adjuvant chemotherapy consisting of UFT/ LV may be a prognostic factor of recurrence in stage III CRC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACADEMIC medical centers
*COLON tumors
*COMBINED modality therapy
*MEDICAL records
*MULTIVARIATE analysis
*NEUTROPENIA
*HEALTH outcome assessment
*T-test (Statistics)
*TREATMENT effectiveness
*PROPORTIONAL hazards models
*RETROSPECTIVE studies
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*PROGNOSIS
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 09615423
- Volume :
- 23
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer Care
- Publication Type :
- Academic Journal
- Accession number :
- 95702081
- Full Text :
- https://doi.org/10.1111/ecc.12120