Quality of life after surgery in individuals with familial colorectal cancer: does extended surgery have an adverse impact?

Background There is controversy regarding the optimum surgical treatment of patients presenting with colorectal cancer with known or suspected genetic cancer syndromes. Although standard segmental resection may be curative, a high risk of metachronous malignancy leads many to advocate extended surgery. The current study was designed to assess whether or not extended surgery adversely impacts quality of life compared to segmental surgery. Methods Records at The Royal Melbourne Hospital Family Cancer Clinic were searched in order to identify patients with suspected high risk familial colon cancer. Patients who underwent surgery were identified and mailed two Standardized Quality of Life Questionnaires ( EORTC QLQ- C30 and EORTC QLQ- CR38). Results Fifty respondents met the inclusion criteria. None of the 15 patients whose primary operation was an extended procedure developed a metachronous cancer. Seventeen of the 35 (48.67%) who had an initial segmental resection had subsequent surgery for metachronous cancer. At the time of the questionnaire, 27 had extended surgery and 23 had segmental operations. The overall global health status and quality of life was very similar between the two groups. Conlcusion This study confirms that there is a high rate of metachronous cancer for patients undergoing segmental resection for hereditary colon cancer. Quality of life following either segmental or extended resection is not significantly different. Consequently, it is reasonable to recommend extended surgery for most patients with high risk hereditary colon cancer. [ABSTRACT FROM AUTHOR]