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Tbr2 Is Required to Generate a Neural Circuit Mediating the Pupillary Light Reflex.
- Source :
-
Journal of Neuroscience . 4/16/2014, Vol. 34 Issue 16, p5447-5453. 7p. - Publication Year :
- 2014
-
Abstract
- There are ~20 types of retinal ganglion cells (RGCs) in mice, each of which has distinct molecular, morphological, and physiological characteristics. Each RGC type sends axon projections to specific brain areas that execute light-dependent behaviors. Here, we show that the T-box transcription factor Tbr2 is required for the development of several RGC types that participate in non-image-forming circuits. These types are molecularly distinct, project to non-image-forming targets, and include intrinsically photosensitive RGCs. Tbr2 mutant mice have reduced retinal projections to non-image-forming nuclei and an attenuated pupillary light reflex. These data demonstrate that Tbr2 acts to execute RGC type choice and/or survival in a set of RGCs that mediates light-induced subconscious behaviors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEURAL circuitry
*PUPIL (Eye)
*RETINAL ganglion cells
*AXONS
MICE anatomy
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 34
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 95641909
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.0035-14.2014