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Inhibition of inflammatory response in LPS induced macrophages by 9-KOTE and 13-KOTE produced by biotransformation.
- Source :
-
Enzyme & Microbial Technology . May2014, Vol. 58-59, p36-43. 8p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] α-Linolenic acid (ALA) was biotransformed by Aspergillus niger into species with different degree of oxygenation. [•] The main biotransformation products were characterized by LC-MS/MS analyses. [•] Their anti-inflammatory potential was evaluated with NO and TNF-α quantification in LPS-stimulated RAW264.7 macrophages. [•] The isomeric ketoacids 9-KOTE and 13-KOTE were the most active. [•] Biotransformation was successfully employed for the production of potential analogs to lipid mediators. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01410229
- Volume :
- 58-59
- Database :
- Academic Search Index
- Journal :
- Enzyme & Microbial Technology
- Publication Type :
- Academic Journal
- Accession number :
- 95628958
- Full Text :
- https://doi.org/10.1016/j.enzmictec.2014.02.011