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Novel synthesis of nitro-quinoxalinone derivatives as aldose reductase inhibitors.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2014, Vol. 24 Issue 9, p2086-2089. 4p. - Publication Year :
- 2014
-
Abstract
- Abstract: A novel, non-acid series of nitroquinoxalinone derivatives was synthesized and tested for their inhibitory activity against aldose reductase as targeting enzyme. All active compounds displayed an 8-nitro group, and showed significant activity in IC50 values ranging from 1.54 to 18.17μM. Among them 6,7-dichloro-5,8-dinitro-3-phenoxyquinoxalin-2(1H)-one (7e), exhibited the strongest aldose reductase activity with an IC50 value of 1.54μM and a good SAR (structure–activity relationship) profile. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 24
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 95621808
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.03.053