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Anticancer Activity of Half-Sandwich RhIII and IrIII Metalla-Prisms Containing Lipophilic Side Chains.
- Source :
-
ChemPlusChem . Apr2014, Vol. 79 Issue 4, p610-618. 9p. - Publication Year :
- 2014
-
Abstract
- Two hexacationic pentamethylcyclopentadienyl rhodium(III) and iridium(III) metalla-prisms, [(η5-C5Me5)6M6(μ3-tpt-κ N)2(μ4-C6HRO4-κ O)3]6+ (tpt=2,4,6-tri-(pyridin-4-yl)-1,3,5-triazine; R=(CH2)10CH3; M=Rh, [ 3]6+; M=Ir, [ 4]6+) isolated as their triflate salts, have been synthesised from the dinuclear complexes (η5-C5Me5)2M2(μ4-C6HRO4-κ O)Cl2 (M=Rh, 1; M=Ir, 2) and AgCF3SO3. The antiproliferative activity of the neutral and cationic complexes has been evaluated in vitro in human cancer cell lines. The positively charged metalla-prisms appear to target mitochondria, which ultimately induce apoptosis in cancer cells. All biological studies suggest that the rhodium derivative [ 3][CF3SO3]6 possesses excellent activities, not only in vitro but also in vivo in tumour-induced C57L6/J mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTINEOPLASTIC agents
*LIPOPHILICITY
*RHODIUM
*IRIDIUM
*APOPTOSIS
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 21926506
- Volume :
- 79
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- ChemPlusChem
- Publication Type :
- Academic Journal
- Accession number :
- 95562500
- Full Text :
- https://doi.org/10.1002/cplu.201300425