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7,3',4'-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice.

Authors :
Bo-Bae Kim
Jong Rhan Kim
Ji Hye Kim
Young Ah Kim
Jun Seong Park
Myeong-Hun Yeom
Hyong Joo Lee
Ki Won Lee
Nam Joo Kang
Source :
Evidence-based Complementary & Alternative Medicine (eCAM). 2013, Vol. 2013, p1-10. 10p. 1 Diagram, 4 Graphs.
Publication Year :
2013

Abstract

Atopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing. The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing. Epidemiological studies suggest that soybean and its isoflavones have immunoregulatory activities. Here, we reportthat7,3',4' -trihydroxyisoflavone(7,3ʹ,4ʹ-THIF),amajormetaboliteofdaidzin,effectivelyinhibitedlipopolysaccharide(LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced β-hexosaminidase secretion in RBL-2H3 cells. Moreover, 7,3ʹ,4ʹ-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration. It also decreased protease-activated receptor (PAR)-2 and IL-4 expression and increased filaggrin expression in skin lesions of NC/Nga mice. These results suggest that 7,3ʹ,4ʹ-THIF improves Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1741427X
Volume :
2013
Database :
Academic Search Index
Journal :
Evidence-based Complementary & Alternative Medicine (eCAM)
Publication Type :
Academic Journal
Accession number :
95495608
Full Text :
https://doi.org/10.1155/2013/636597