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7,3',4'-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 2013, Vol. 2013, p1-10. 10p. 1 Diagram, 4 Graphs. - Publication Year :
- 2013
-
Abstract
- Atopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing. The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing. Epidemiological studies suggest that soybean and its isoflavones have immunoregulatory activities. Here, we reportthat7,3',4' -trihydroxyisoflavone(7,3ʹ,4ʹ-THIF),amajormetaboliteofdaidzin,effectivelyinhibitedlipopolysaccharide(LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced β-hexosaminidase secretion in RBL-2H3 cells. Moreover, 7,3ʹ,4ʹ-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration. It also decreased protease-activated receptor (PAR)-2 and IL-4 expression and increased filaggrin expression in skin lesions of NC/Nga mice. These results suggest that 7,3ʹ,4ʹ-THIF improves Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of isoflavones
*ANIMAL experimentation
*ATOPIC dermatitis
*CELL culture
*HISTOLOGY
*IMMUNOHISTOCHEMISTRY
*INTERLEUKINS
*MICE
*MOLECULAR structure
*NITRIC oxide
*RESEARCH funding
*STAINS & staining (Microscopy)
*T-test (Statistics)
*TUMOR necrosis factors
*ISOFLAVONES
*LIPOPOLYSACCHARIDES
*IN vitro studies
*SYMPTOMS
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2013
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 95495608
- Full Text :
- https://doi.org/10.1155/2013/636597